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Pan An: Smoking Increase Risk of Cardiovascular Diseases to People with Diabetes

Pan An: Smoking Increase Risk of Cardiovascular Diseases to People with Diabetes

Smoking poses a global challenge to public health, whose harm is well known by all, especially that it will greatly increase the risk of cancer(particularlly lung cancer) and cardiovascular diseases. However, there is little knowledge about the relation between smoking and diabetes.


Recently, Professor Pan An and his colleagues from School of public health, Tongji Medical School successively published academic papers in Circulation ( IF 14.95) and The Lancet Diabetes & Endocrinology( IF 9.19) to systematically illustrate the relation between smoking & diabetes as well as the harm smoking may do to patients with diabetes.


On Angust 26th, the paper titled Relation of smoking with total mortality and cardiovascular events among patients with diabetes: a meta-analysis and systematic review was published on Circulation authored by Pan An and his colleagues. The paper made a detailed analysis of the data of 89 teams’ research. It turned out that for patients with diabetes, smoking considerably increases their risk of suffering from all kinds of cardiovascular diseases such as coronary atherosclerotic heart disease,cerebral apoplexy, peripheral vascular disease and heart failure etc. It also enhance the risk of total mortality and death caused by cardiovascular diseases. However these risks will drop prominently after smoking is quit, which indicates the importance of quiting smoking for patients with diabetes. So for them, quitting smoking is a main target for diabetes control.


On Sept 18th, the paper named Relation of active, passive, and quitting smoking with incident type 2 diabetes: a systematic review and meta-analysis was published on The Lancet, in which Pan summarized the data of 600 people from 88 team’s research. It turned out that compared with non-smokers, active smoking increases the risk of diabetes by 37%, however after quiting smoking, the rate will drop to 14%. Among non-smokers, secondhand smoking increases the risk of diabetes by 22%. The paper also pointed out that there is a dose reaction relation between the extent of smoking and the risk of diabetes, which means that the more you smoke, the higher your risk of developing diabetes will be. Another important discovery is that within a short time( 5 years) after quitting smoking, the risk of diabetes may not decrease, however in a long time, the risk will drop prominently to the level of non-smokers. In a short time, quitting smoking may lead to weight gain, influence blood sugar control and change metabolism, which smoking quitters should attach great importance to. Further research also requires exploring its mechanism and take corresponding measures. According to the latest survey on the global smoking condition and diabetes, the authors estimate that diabetes cases arising from smoking have reached 27,800,000( taking up 11.7% of male diabetes patients and 2.4 of female ones) However, nearly half men in China smoke so the rate of diabetes arising from smoking is even higher.


The two papers made a systematic analysis of the relation between smoking and diabetes, they are at present the most comprehensive analysis on this topic in the world. The papers illustrated the harm smoking does to patients with diabetes and provided scientific evidence for a comprehensive realization of the importance of smoking control and the future cigarette control policy. However, for the Chinese, tobacco is also a great problem of public health. The harm smoking and secondhand smoking may cause such as leading to cancer, cardiovascular diseases and diabetes should also be widely concerned.


Co- authors of these two papers include Professor Wu Tangchun from School of Public Health, Professor Frank Hu from School of Public Health, Harvard University, Wang Yeli and Mohammad Talaei ,Ph.D student from School of Public Health, National University of Singapore.

Professor Pan An is a Young-overseas-high-level-talents-introduction-plan scholar. He got his Ph.D in 2009. From 2009 to 2012 he was in Harvard University for academic exchanges and in the next three years, he worked in School of Public HealthNational University of Singapore as assistant professor and Ph.D instructor. For a long time, Pan has been devoted to the research on epidemiology of chronic metabolic diseases like diabetes. In recent years, he has published over 35 academic papers in the top magazines of the international medical circle including New England Journal of Medicine, NEJM and Journal of American Medical Association, JAMA.