HUSTers have achieved a number of scientific breakthroughs recently. Let’s have a look!
Team from School of Public Health discovers subtype-specific association of mitochondrial DNA copy number with poststroke/TIA outcomes
On March 21st, a team from the School of Public Health, led by Prof. Wang Chaolong, jointly published a research paper with a team from Beijing Tiantan Hospital, led by Prof. Wang Yongjun, in medical journal Stroke titled Subtype-specific association of mitochondrial DNA copy number with poststroke/TIA outcomes in 10,241 patients in China. Based on an observational prospective cohort analysis on patients with ischemic stroke or transient ischemic attack enrolled in the Third China National Stroke Registry, the research discovered association between mitochondrial DNA copy number and stroke recurrence, disability, and all-cause mortality. It promotes the study of the prognostic mechanism of stroke and has important guiding significance for improving the prognosis of stroke patients in the future.
Original paper: https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.045069
Team from Tongji Medical College discovers key mechanism by which EP400 regulates oocyte quality and zygotic genome activation
EP400调控卵母细胞质量和早期胚胎发育的分子机理
On March 18th, Prof. Zhou Liquan and Prof. Xiang Wenpei from the Institute of Reproductive Health and Prof. He Ximiao from the School of Basic Medicine published a research paper titled Chromatin Modifier EP400 Regulates Oocyte Quality and Zygotic Genome Activation in Mice in Advanced Science. The research discovered that EP400 plays an essential role in maintaining oocyte quality and in regulating zygotic genome activation for early embryo development in mice.
Original paper: https://onlinelibrary.wiley.com/doi/10.1002/advs.202308018
Team from School of Chemistry and Chemical Engineering makes new breakthrough in spin chains
图为零维到一维结构与磁性的拓扑转变（a为晶体结构，b为磁化率）
On March 15th, the latest research result from a team led by Prof. Lu Hongcheng Construction of Ideal One-Dimensional Spin Chains by Topochemical Dehydration/Rehydration Route, was published in Journal of the American Chemical Society. The team invented topochemical dehydration/rehydration approach and further extended it to S = 3/2 1D chains, thus opening the possibility of obtaining other low-dimensional spin lattices.
Original paper: https://pubs.acs.org/doi/10.1021/jacs.3c13902
Team from School of Materials Science and Engineering makes new progress in 3D printing metamaterials
图为木材启发超材料催化剂
On March 7th, a team from the School of Materials Science and Engineering, led by Prof. Shi Yusheng, and a team from the City University of Hong Kong, led by Academician Lv Jian, published their collaborative research findings on Nature Communications. The research paper was titled Wood-inspired metamaterial catalyst for robust and high-throughput water purification, where the teams proposed design methods for metamaterials inspired by Douglas fir wood. This research demonstrates the rational and harmonious integration of structural and functional design in robust and high throughput water purification, and can inspire the development of various flow catalysts, flow batteries, and functional 3D-printed materials.
Original paper: https://www.nature.com/articles/s41467-024-46337-1
Team from School of Mechanical Science and Engineering publishes latest results on programmable photonic integrated circuits
图为非易失可编程光子芯片示意图
On March 5th, teams from the School of Mechanical Science and Engineering, respectively led by Prof. Liu Shiyuan and Prof. Zhu Jinlong, published their latest research paper in International Journal of Extreme Manufacturing, titled Pixelated non-volatile programmable photonic integrated circuits with 20-level intermediate states. The research lays the foundation for laser-writing ultra-high-level (20 levels and even more) programmable photonic systems and metasurfaces based on phase change materials, which could catalyze diverse applications such as programmable neuromorphic photonics, biosensing, optical computing, photonic quantum computing, and reconfigurable metasurfaces.
Original paper: http://www.ijemnet.com/en/article/doi/10.1088/2631-7990/ad2c60
Team from Wuhan National Laboratory for Optoelectronics develops high-fidelity high-dimensional quantum gates
图为三维X1门的输入态、四层相位面和对应输出态
Recently, Multi-Dimensional Photonics Laboratory, led by Prof. Wang Jian, made significant breakthroughs in field of light regulating quantum information processing. On March 5th, the team published their latest research outcomes in Light: Science & Applications, titled Ultrahigh-fidelity spatial mode quantum gates in high-dimensional space by diffractive deep neural networks. The outcomes reflect the research strength of this team and opens up a new path for the development of quantum computing.
Original paper: https://www.nature.com/articles/s41377-024-01409-1
Team from School of Life Science and Technology develops a new approach to detect the activity of the receptor in neurons
图为神经细胞中内源GPCR的活性检测探针构建和信号检测示意图
On March 5th, a team from the School of Life Science and Technology, led by Prof. Liu Jianfeng, published their research paper online in Nature Communications, titled Specific pharmacological and Gi/oprotein responses of some native GPCRs in neurons. The team revealed different profiles in the Gi/o protein subtypes-mediated responses, and differences in the potencies of some ligands even at similar receptor expression levels. The research results show the importance of using biosensors compatible with primary cells for evaluating the activities of endogenous GPCRs in their native environment.
Original paper: https://www.nature.com/articles/s41467-024-46177-z
Team from School of Basic Medicine makes new progress in the mechanism of the development of memory T cells
On March 4th, a team from the School of Basic Medicine, led by Prof. Huang Bo, published latest research outcome titled Sustained AhR activity programs memory fate of early effector CD8+ T cells in PNAS. The research reveals that AhR functions as a pivotal transcription factor that programs the memory fate of early CD8+ effector T cells, which has theoretical and practical significance to T cell–based tumor immunotherapy.
Original paper: https://www.pnas.org/doi/10.1073/pnas.2317658121
Team from School of Physics observes non-Hermitian skin effect in thermal diffusion
图为扩散NHSE的实验观测
On March 2nd, a team from the School of Physics, led by Prof. Zhu Xuefeng, made joint progress in non-Hermitian skin effect in thermal diffusion with a team from Zhejiang University, led by Prof. Li Ying. Their research paper was published in Science Bulletin, titled Observation of non-Hermitian skin effect in thermal diffusion. This research provides a platform for exploration of non-Hermitian physics in the diffusive systems, which has important applications in efficient heat collection, highly sensitive thermal sensing and others.
Original paper: https://www.sciencedirect.com/science/article/abs/pii/S2095927324001427?via%3Dihub
Team from School of Pharmacy publishes latest research outcomes
On March 1st, a team from the School of Pharmacy, led by Prof. Wang Rui, published their research paper in Nucleic Acids Research, titled Bioorthogonal labeling and profiling of N6-isopentenyladenosine (i6A) modified RNA. Currently, the team is actively exploring the application of this technique in applied clinical research, focusing on future revolutionary progress in disease prevention, diagnosis and treatment.
Original paper: https://doi.org/10.1093/nar/gkae150
Team from School of Optical and Electronic Information makes new breakthrough in near-field optical imaging
图为原子工程调控面内各向异性声子极化激元
On March 1st, a team from the School of Optical and Electronic Information, led by Prof. Li Peining, published their research paper in Nature Nanotechnology, titled Van der Waals quaternary oxides for tunable low-loss anisotropic polaritonics. The research realized tunable phonon polariton, enriched the van der Waals system for the study of anisotropic polaritonics and unlocked new prospects for nanophotonic and optoelectronic applications.
Original paper: https://www.nature.com/articles/s41565-024-01628-y
Written by: Yang Kunjie
Edited by: Wang Xinyi, Chang Wen, Peng Yumeng
Chinese
